Blar i forfatter "Kogner, Per"

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    • Autocrine Prostaglandin E-2 Signaling Promotes Tumor Cell Survival and Proliferation in Childhood Neuroblastoma 

      Rasmuson, Agnes; Kock, Anna; Fuskevåg, Ole-Martin; Kruspig, Björn; Simon-Santamaria, Jaione; Gogvadze, Vladimir; Johnsen, John Inge; Kogner, Per; Sveinbjørnsson, Baldur (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Prostaglandin E2 (PGE2) is an important mediator in tumor-promoting inflammation. High expression of cyclooxygenase-2 (COX-2) has been detected in the embryonic childhood tumor neuroblastoma, and treatment with COX inhibitors significantly reduces tumor growth. Here, we have investigated the significance of a high COX-2 expression in neuroblastoma by analysis of PGE2 production, the expression pattern ...

    • ERBB3 is a marker of a ganglioneuroblastoma/ganglioneuroma-like expression profile in neuroblastic tumours 

      Wilzén, Annika; Krona, Cecilie; Sveinbjørnsson, Baldur; Kristiansson, Erik; Dalevi, Daniel; Øra, Ingrid; De Preter, Katleen; Stallings, Raymond L.; Maris, John; Versteeg, Rogier; Nilsson, Staffan; Kogner, Per; Abel, Frida (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Background: Neuroblastoma (NB) tumours are commonly divided into three cytogenetic subgroups. However, by unsupervised principal components analysis of gene expression profiles we recently identified four distinct subgroups, r1-r4. In the current study we characterized these different subgroups in more detail, with a specific focus on the fourth divergent tumour subgroup (r4). Methods: Expression ...

    • Inhibition of chemerin/CMKLR1 axis in neuroblastoma cells reduces clonogenicity and cell viability in vitro and impairs tumor growth in vivo 

      Tümmler, Conny; Snapkov, Igor; Wickström, Malin; Moens, Ugo; Ljungblad, Linda; Elfman, Maria; Winberg, Jan-Olof; Kogner, Per; Johnsen, John Inge; Sveinbjørnsson, Baldur (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-27)
      Pro-inflammatory cells, cytokines, and chemokines are essential in promoting a tumor supporting microenvironment. Chemerin is a chemotactic protein and a natural ligand for the receptors CMKLR1, GPR1, and CCRL2. The chemerin/CMKLR1 axis is involved in immunity and inflammation, and it has also been implicated in obesity and cancer.<p> In neuroblastoma, a childhood tumor of the peripheral nervous ...

    • Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma 

      Hald, Øyvind Holsbø; Olsen, Lotte; Gallo-Oller, Gabriel; Elfman, Lotta Helena Maria; Løkke, Cecilie; Kogner, Per; Sveinbjørnsson, Baldur; Flægstad, Trond; Johnsen, John Inge; Einvik, Christer (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-12)
      Abnormal increases in nucleolar size and number caused by dysregulation of ribosome biogenesis has emerged as a hallmark in the majority of spontaneous cancers. The observed ribosome hyperactivity can be directly induced by the MYC transcription factors controlling the expression of RNA and protein components of the ribosome. Neuroblastoma, a highly malignant childhood tumor of the sympathetic nervous ...

    • MYCN-regulated miRNAs Inhibit Secretion of the Tumor Suppressor DICKKOPF-3 (DKK3) in Neuroblastoma 

      Haug, Bjørn Helge; Henriksen, Jørn Remi; Buechner, Jochen; Kogner, Per; Martinsson, Tommy; Flægstad, Trond; Sveinbjørnsson, Baldur; Einvik, Christer (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      The MYCN oncogene is frequently amplified in neuroblastoma. It is one of the most consistent markers of a bad prognosis for this disease. Dickkopf-3 (DKK3) is a secreted protein of the Dickkopf family of Wnt regulators. It functions as a tumor suppressor in a range of cancers, including neuroblastoma. MYCN was recently found to downregulate DKK3 mRNA. In this study, we show that MYCN knockdown in ...

    • Rho-associated kinase is a therapeutic target in neuroblastoma 

      Dyberg, Cecilia; Fransson, Susanne; Andonova, Teodora; Sveinbjørnsson, Baldur; Lannerholm-Palm, Jessika; Olsen, Thale Kristin; Forsberg, David; Herlenius, Eric; Martinsson, Tommy; Brodin, Bertha; Kogner, Per; Johnsen, John Inge; Wickström, Malin (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-24)
      Neuroblastoma is a peripheral neural system tumor that originates from the neural crest and is the most common and deadly tumor of infancy. Here we show that neuroblastoma harbors frequent mutations of genes controlling the Rac/Rho signaling cascade important for proper migration and differentiation of neural crest cells during neuritogenesis. RhoA is activated in tumors from neuroblastoma ...

    • The role of formyl peptide receptor 1 (FPR1) in neuroblastoma tumorigenesis 

      Snapkov, Igor; Öqvist, Carl Otto; Figenschau, Yngve Anton; Kogner, Per; Johnsen, John Inge; Sveinbjørnsson, Baldur (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-07-18)
      Background: Formyl peptide receptor 1 (FPR1) is a G protein-coupled receptor mainly expressed by the cells of myeloid origin, where it mediates the innate immune response to bacterial formylated peptides. High expression of FPR1 has been detected in various cancers but the function of FPR1 in tumorigenesis is poorly understood. Methods: Expression of FPR1 in neuroblastoma cell lines and primary ...

    • SYK Inhibition Potentiates the Effect of Chemotherapeutic Drugs on Neuroblastoma Cells in Vitro 

      Tümmler, Conny; Dumitriu, Gianina; Wickström, Malin; Coopman, Peter; Valkov, Andrey Yurjevich; Kogner, Per; Johnsen, John Inge; Moens, Ugo; Sveinbjørnsson, Baldur (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-10)
      Neuroblastoma is a malignancy arising from the developing sympathetic nervous system and the most common and deadly cancer of infancy. New therapies are needed to improve the prognosis for high-risk patients and to reduce toxicity and late effects. Spleen tyrosine kinase (SYK) has previously been identified as a promising drug target in various inflammatory diseases and cancers but has so far not ...

    • Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance 

      Wickström, Malin; Dyberg, Cecilia; Milosevic, Jelena; Einvik, Christer; Calero, Raul; Sveinbjørnsson, Baldur; Sandén, Emma; Darabi, Anna; Siesjö, Peter; Kool, Marcel; Kogner, Per; Baryawno, Ninib; Johnsen, John Inge (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11-25)
      The DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) is commonly overexpressed in cancers and is implicated in the development of chemoresistance. The use of drugs inhibiting MGMT has been hindered by their haematologic toxicity and inefficiency. As a different strategy to inhibit MGMT we investigated cellular regulators of MGMT expression in multiple cancers. Here we show a ...